TOPAcademic data
Academic data


Manda Koso’s possibilities seen from a scientific point of view.

We identify the components contained in Manda Koso and analyze its effects to carry out scientific verification through an experiment involving test tubes and animals, as well as by taking advantage of statistics. Today, in many areas of anti-oxidation, anti-aging, immunity, and stress, Manda Koso’s academic data is published on a number of research papers and magazines.
In addition, Manda Koso has not obtained permission or notification as a food for specified health uses and a functional food.

Published academic themes and titles.

Anti-oxidation

[Title]

Free Radical Scavenging Action of MANDA(Japanese)


[Journal]
Basic and Clinical

[Author]
Kawai, et al.


[Overview]

Manda Koso erased causal substances (free radical) causing damage to the human body and cells.


[Target]
Test tube

[Title]

Effects of a fermented vegetable product on hemolysis and lipid preoxidation of Japanese flounder erythrocytes


[Journal]
Fisheris Science

[Author]
Ashida, et al.


[Overview]

Manda Koso suppressed flatfish’s red blood cells from damage due to oxidation.


[Target]
flounder, erythrocytes

[Title]

Effects of a fermented vegetable product on hemolysis and lipid peroxidation of Japanese flounder erythrocytes


[Journal]
Fisheris Science

[Author]
Ashida, et al.


[Overview]

Manda Koso suppressed flatfish’s blood serum and liver from damage due to oxidation.
Manda Koso caused an activation of an enzyme that prevents the human body and cells from oxidation.


[Target]
flounder, Serum, liver

Cancers

[Title]

Anti tumor and Immunopotentiating Effects of Manda Enzyme


[Journal]

Natural Product Sciences

[Author]
Huang, et al.


[Overview]

Manda Koso extended the span of life for cancer-bearing mice.

Manda Koso suppressed cancer cells from growing larger.

Manda Koso caused an activation of lymphocytes that prevents the growth of cancer cells.


[Target]
mouse, whole body

[Title]

Postoperative Effect of Manda on NK Cell Activity in Cancer Patients(Japanese)


[Journal]

Biotherapy

[Author]
Yamamoto, et al.


[Overview]

It is known that the immunity declines after a surgery for cancer. Test results confirmed that Manda Koso helped recover weakening of the immune system after surgery early.


[Target]
human, whole body

[Title]

植物発酵食品の抗腫瘍効果と肺転移におよぼす影響(Japanese)


[Journal]

The Japanese Journal of Constitutional Medicine

[Author]
Kimura, et al.


[Overview]

Manda Koso suppressed the growth of cancer cells in a mouse.

Manda Koso suppressed the transition of cancer to the lungs of a mouse.


[Target]
mouse, whole body

[Title]

Inhibition of human breast cancer cell growth and enzymatic activity by a fermented nutraceutical: an in vitro and in vivo study


[Journal]

Annuals of the New York Academy of Sciences

[Author]
Marotta, et al.


[Overview]

The results of in vivo tests in mice indicated that Manda Koso decreased human mammary carcinoma and increased the chances of survival.


[Target]
mouse, breast cancer

Cancers/Anti-oxidation

[Title]

ANTIOXIDANT AND ANTITUMOR EFFECTS OF MANDA


[Journal]

Biochemical Archives

[Author]
Kim, et al.


[Overview]

Manda Koso suppressed the liver and lung from damages due to oxidation.

Manda Koso suppressed the growth of cancer cells and a transition of cancer cells to the lungs.


[Target]
mouse, liver, lung

[Title]

In vitro antioxidant and anticancer activities of extracts from a fermented food


[Journal]

Journal of Food Biochemistry

[Author]
Kim, et al.


[Overview]

Test results confirmed that Manda Koso contains the components that suppress the growth of cancer cells and the components that erase substances causing the oxidation of the human body.


[Target]
Test tube

Stress

[Title]

Manda Suppresses Emotional Stress-Induced Stomach Ulcers in Rats


[Journal]

International Journal of Stress Management

[Author]
Kawai, et al.


[Overview]

When there is acute stress, the stomach digests itself, causing an ulcer (hole). The results of a test using rats confirmed that Manda Koso suppressed the development of gastric ulcers.


[Target]
rats, Stomach ulcer

[Title]

Effect of a dietary fermented vegetable product on the heat shock response of Japanese flounder Paralichthys olivaceus


[Journal]

Fisheris Science

[Author]
Ashida, et al.


[Overview]

Test results confirmed that the administration of Manda Koso in flatfish increased the amount of protein that protects the body from damage due to heat and environmental changes.


[Target]
flounder, Stress from outside the body

Alcohol consumption

[Title]

アルコール投与後の血中アセトアルデヒド濃度に与えるMANDAの抑制効果(Japanese)


[Journal]

Progress in Medicine

[Author]
Kawai, et al.


[Overview]

Manda Koso reduced the amount of a substance (acetaldehyde), which causes hungover and deterioration of liver function due to drinking.


[Target]
uman, liver

Sexual function

[Title]

Experimental and Clinical Studies on the Effects of Manda Enzyme on Male Sexual Functions(Japanese)


[Journal]

Journal of the Japanese Society of Impoence Research

[Author]
Koshido, et al.


[Overview]

It is known that the decline of androgen causes sexual dysfunction and other symptoms. Test results showed that the consumption of Manda Koso increased the amount of androgen, indicating the possibilities of improving sexual function.


[Target]
human, Sexual dysfunction

Infectious illness

[Title]

Immunostimulatory effects of fermented vegetable product on the non-specific immunity of Japanese flounder Paralichthys olivaceus


[Journal]

Fisheris Science

[Author]
Ashida, et al.


[Overview]

The administration of Manda Koso in flatfish activated white blood cells and improved immunity.


[Target]
flounder, whole body

Menopause/Osteoporosis

[Title]

Effects of a fermented vegetable product on fat deposition and bone metabolism in ovariectomized rats


[Journal]

Journal of Nutritional Science and Vitaminology

[Author]
Shimada, et al.


[Overview]

Test results showed that Manda Koso suppressed weight gain and an increase in the body fat of a rat with declined female hormones after oophorectomy.


[Target]
rats, Weight gain, body fat

Anti-oxidation/Anti-aging

[Title]

MANDA SCAVENGES FREE RADICALS AND INHIBITS LIPID PEROXIDATION IN IRON-INDUCED EPILEPTIC FOCUS IN RATS


[Journal]
Food and free radicals

[Author]
Kawai, et al.


[Overview]

Manda Koso is expected to suppress nerve damage, traumatic convulsive seizures, and aging.


[Target]
rats, Cranial nerve

[Title]

Manda, a Fermented Natural Food, Suppresses Lipid Peroxidation in the Senescent Rat Brain


[Journal]

Neurochemical Research

[Author]
Kawai, et al.


[Overview]

It is believed that Manda Koso is effective in suppressing the body and cells from damage due to oxidation and oxidative damage of the brain in the elderly.


[Target]
rats, brain

Formation of blood clot

[Title]

Isolation and Partial Characterization of a Polysaccharide with Antithrombin Activity against Blood Coagulation in Manda, a Fermented Natural Food


[Journal]

Agriultural Chemistry and Biotechnology

[Author]
Kim, et al.


[Overview]

Test results revealed that Manda Koso contains components that prevent a blood clot.


[Target]
Test tube, Thrombus

Clinical symptoms/Drug toxicity

[Title]

血液透析患者の不定愁訴に対する万田酵素の基礎的ならびに臨床的研究(Japanese)


[Journal]

Basic and Clinical

[Author]
Takara, et al.


[Overview]

Manda Koso improved indefinite complaints (a feeling of fatigue, stiff shoulders, stiff muscles and joints, heaviness of the head, and bloating) in hemodialysis patients.


[Target]
human, whole body

Radiation damages

[Title]

“Shokubutsu hakko sanbutsu no X-sen shosha ni taisuru bougyo kouka – shocho no senka saisei ni ataeru eikyo”
(The defensive effects of a fermented vegetable product on X-ray exposure – effects on the regeneration of intestinal crypts)


[Journal]

The Journal of Japan Mibyou System

[Author]
Ashida, et al.


[Overview]

Test results confirmed that Manda Koso is effective in improving the recovery of small intestine tissues damaged from exposure to radiation and reducing radiation damage.


[Target]
mouse, Small intestine

Growth/Feedstuff

[Title]

Effects of a fermented vegetable product on hemolysis and lipid peroxidation of Japanese flounder erythrocytes


[Journal]
Suisanzoshoku

[Author]
Ashida, et al.


[Overview]

Manda Koso suppressed flatfish’s liver from damage due to oxidation.

By giving Manda Koso to flatfish, the weight increased slightly.


[Target]
flounder, liver

[Title]

Effects of fermented plant product on growth performance, some blood variables, carcase characteristics, and intestinal histology in broilers


[Journal]

British Poultry Science

[Author]
Lokaewmanee, et al.


[Overview]

The administration of plant-fermented substances increased the live weight gain and feed efficiency of young chicken.

The administration of plant-fermented substances significantly developed the intestinal epithelial tissues of young chicken.

The growth promotion of young chicken brought certain advantages such as an increased feed efficiency and short-term breeding.


[Target]
chicken, Intestine, body weight